Dental Problems

Intraepithelial Carcinoma

ToothIntraepithelial carcinoma is also known as carcinoma in situ. Severe dysplastic changes in a white lesion indicates considerable risk of cancer development. The more severe condition of dysplasia merges with the condition which is known as carcinoma in situ. This precancer condition is more common on the skin but it can also occur on the mucous membrane. In this article, there is a brief discussion on the

intraepithelial carcinoma

. Read on to know more.

Clinical features:

  • Age and sex:

    Male predilection and it occurs more commonly in the elder people.

  • Sites:

    the most common sites or areas are tongue, lips and floor of mouth.

  • Appearance:

    The appearance of the lesions may be like erythroplakia and like leukoplakia. It might be a combination of erythroplakia and leukoplakia, ulcerated lesion, white and ulcerated lesion, ulcerated and red lesion or might be non-specific.

Histopathological features:

  • Keratin may not or may be present on or inside the surface of lesion but if present it is more apt to be parakerating rather than orthokeratin.
    Loss of orientation and polarity of cells.
  • A sharp line of division between the altered and normal epithelium extending from the surface down to the connective tissue rather than the blending of epithelia.
  • In some cases, there is appearance of hyperplasia of the altered epithelium, while in others there might be atrophy.
  • An increase in cytoplasmic or nuclear ratio and nuclear hyperchromatis are seen sometimes.
  • It is also very unusual to find the multiple sites of carcinoma in situ interspersed by the essentially normal appearing of epithelium which produces multi-focal carcinoma in situ.


  • No uniformly accepted treatment.
  • Lesion might be surgically excised cauterized and even exposed to solid carbon dioxide.

The above article discusses about

intraepithelial carcinoma


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